RapamycinFungusV1, Main, Exploration, bibRecord, 000A76

Inhibition of autophagy contributes to the toxicity of cadmium telluride quantum dots in Saccharomyces cerevisiae.

Identifieur interne : 000A76 ( Main/Exploration ); précédent : 000A75; suivant : 000A77

Inhibition of autophagy contributes to the toxicity of cadmium telluride quantum dots in Saccharomyces cerevisiae.

Auteurs : Junpeng Fan ; Ming Shao ; Lu Lai [République populaire de Chine] ; Yi Liu [République populaire de Chine] ; Zhixiong Xie [République populaire de Chine]

Source :

International journal of nanomedicine [ 1178-2013 ] ; 2016.

RBID : pubmed:27524895

Descripteurs français

KwdFr :
- Animaux (MeSH), Autophagie (effets des médicaments et des substances chimiques), Boîtes quantiques (toxicité), Composés du cadmium (toxicité), Protéines à fluorescence verte (métabolisme), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (ultrastructure), Sirolimus (pharmacologie), Tellure (toxicité), Vacuoles (effets des médicaments et des substances chimiques), Vacuoles (ultrastructure).
MESH :
- effets des médicaments et des substances chimiques : Autophagie, Saccharomyces cerevisiae, Vacuoles.
- métabolisme : Protéines à fluorescence verte.
- pharmacologie : Sirolimus.
- toxicité : Boîtes quantiques, Composés du cadmium, Tellure.
- ultrastructure : Animaux, Saccharomyces cerevisiae, Vacuoles.

English descriptors

KwdEn :
- Animals (MeSH), Autophagy (drug effects), Cadmium Compounds (toxicity), Green Fluorescent Proteins (metabolism), Quantum Dots (toxicity), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (ultrastructure), Sirolimus (pharmacology), Tellurium (toxicity), Vacuoles (drug effects), Vacuoles (ultrastructure).
MESH :
- chemical , metabolism : Green Fluorescent Proteins.
- chemical , pharmacology : Sirolimus.
- chemical , toxicity : Cadmium Compounds, Tellurium.
- drug effects : Autophagy, Saccharomyces cerevisiae, Vacuoles.
- toxicity : Quantum Dots.
- ultrastructure : Saccharomyces cerevisiae, Vacuoles.
- Animals.

Abstract

Cadmium telluride quantum dots (CdTe QDs) are used as near-infrared probes in biologic and medical applications, but their cytological effects and mechanism of potential toxicity are still unclear. In this study, we evaluated the toxicity of CdTe QDs of different sizes and investigated their mechanism of toxicity in the yeast Saccharomyces cerevisiae. A growth inhibition assay revealed that orange-emitting CdTe (O-CdTe) QDs (half inhibitory concentration [IC50] =59.44±12.02 nmol/L) were more toxic than green-emitting CdTe QDs (IC50 =186.61±19.74 nmol/L) to S. cerevisiae. Further studies on toxicity mechanisms using a transmission electron microscope and green fluorescent protein tagged Atg8 processing assay revealed that O-CdTe QDs could partially inhibit autophagy at a late stage, which differs from the results reported in mammalian cells. Moreover, autophagy inhibited at a late stage by O-CdTe QDs could be partially recovered by enhancing autophagy with rapamycin (an autophagy activator), combined with an increased number of living cells. These results indicate that inhibition of autophagy acts as a toxicity mechanism of CdTe QDs in S. cerevisiae. This work reports a novel toxicity mechanism of CdTe QDs in yeast and provides valuable information on the effect of CdTe QDs on the processes of living cells.

DOI: 10.2147/IJN.S108636
PubMed: 27524895
PubMed Central: PMC4966502

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000995
to stream Main, to step Curation: 000995

Le document en format XML

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<term>Boîtes quantiques (toxicité)</term>
<term>Composés du cadmium (toxicité)</term>
<term>Protéines à fluorescence verte (métabolisme)</term>
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<term>Vacuoles (effets des médicaments et des substances chimiques)</term>
<term>Vacuoles (ultrastructure)</term>
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<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Cadmium Compounds</term>
<term>Tellurium</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines à fluorescence verte</term>
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<keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Quantum Dots</term>
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<front><div type="abstract" xml:lang="en">Cadmium telluride quantum dots (CdTe QDs) are used as near-infrared probes in biologic and medical applications, but their cytological effects and mechanism of potential toxicity are still unclear. In this study, we evaluated the toxicity of CdTe QDs of different sizes and investigated their mechanism of toxicity in the yeast Saccharomyces cerevisiae. A growth inhibition assay revealed that orange-emitting CdTe (O-CdTe) QDs (half inhibitory concentration [IC50] =59.44±12.02 nmol/L) were more toxic than green-emitting CdTe QDs (IC50 =186.61±19.74 nmol/L) to S. cerevisiae. Further studies on toxicity mechanisms using a transmission electron microscope and green fluorescent protein tagged Atg8 processing assay revealed that O-CdTe QDs could partially inhibit autophagy at a late stage, which differs from the results reported in mammalian cells. Moreover, autophagy inhibited at a late stage by O-CdTe QDs could be partially recovered by enhancing autophagy with rapamycin (an autophagy activator), combined with an increased number of living cells. These results indicate that inhibition of autophagy acts as a toxicity mechanism of CdTe QDs in S. cerevisiae. This work reports a novel toxicity mechanism of CdTe QDs in yeast and provides valuable information on the effect of CdTe QDs on the processes of living cells. </div>
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<Abstract><AbstractText>Cadmium telluride quantum dots (CdTe QDs) are used as near-infrared probes in biologic and medical applications, but their cytological effects and mechanism of potential toxicity are still unclear. In this study, we evaluated the toxicity of CdTe QDs of different sizes and investigated their mechanism of toxicity in the yeast Saccharomyces cerevisiae. A growth inhibition assay revealed that orange-emitting CdTe (O-CdTe) QDs (half inhibitory concentration [IC50] =59.44±12.02 nmol/L) were more toxic than green-emitting CdTe QDs (IC50 =186.61±19.74 nmol/L) to S. cerevisiae. Further studies on toxicity mechanisms using a transmission electron microscope and green fluorescent protein tagged Atg8 processing assay revealed that O-CdTe QDs could partially inhibit autophagy at a late stage, which differs from the results reported in mammalian cells. Moreover, autophagy inhibited at a late stage by O-CdTe QDs could be partially recovered by enhancing autophagy with rapamycin (an autophagy activator), combined with an increased number of living cells. These results indicate that inhibition of autophagy acts as a toxicity mechanism of CdTe QDs in S. cerevisiae. This work reports a novel toxicity mechanism of CdTe QDs in yeast and provides valuable information on the effect of CdTe QDs on the processes of living cells. </AbstractText>
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Inhibition of autophagy contributes to the toxicity of cadmium telluride quantum dots in Saccharomyces cerevisiae.

Inhibition of autophagy contributes to the toxicity of cadmium telluride quantum dots in Saccharomyces cerevisiae.

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